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Remodelin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Remodelin图片
CAS NO:1622921-15-6
规格:98%
分子量:363.28
包装与价格:
包装价格(元)
5mg电议
25mg电议
100mg电议

产品介绍
NAT10 inhibitor
CAS:1622921-15-6
分子式:C15H15BrN4S
分子量:363.28
纯度:98%
存储:Store at -20°C

Background:

Remodelin is a potent inhibitor of NAT10 [1].


N-acetyltransferase 10 (NAT10) is the only identified lysine acetyltransferase that acts on microtubules and histones [1]. NAT10 mainly exists in the nucleolus.


Remodelin is a potent NAT10 inhibitor. In lamin A/C depletion (siLMNA) cells, remodelin remodeled nuclear architecture through inhibition of NAT10 lysine acetyltransferase activity. In cells derived from LMNA-mutated HGPS patients and primary MRC5 fibroblasts aged in culture, Remodelin significantly decreased the prevalence of misshapen nuclei. In U2OS cells and normal fibroblasts, remodelin inhibited nuclear shape defects induced by farnesyltransferase inhibitors (FTI). In HGPS cells, remodelin reduced the amount of misshapen nuclei, suggesting that inhibition of NAT10 mediated nuclear shape normalization. Also, remodelin reduced DNA damage signaling, reduced SUN1 accumulation at the nuclear envelope, reduced the levels of autophosphorylated ATM and DNA double-strand break markers γH2AX, and improved chromatin and nucleolar organization. In siLMNA and HGPS cells, remodelin inhibited microtubule anchorage to centrosomes [1].


Reference:
[1].  Larrieu D, Britton S, Demir M, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science, 2014, 344(6183): 527-532.