您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > (-)-epicatechin gallate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
(-)-epicatechin gallate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(-)-epicatechin gallate图片
CAS NO:1257-08-5
规格:98%
分子量:442.37
包装与价格:
包装价格(元)
5mg电议
10mg电议
20mg电议

产品介绍
major catechin in green tea
CAS:1257-08-5
分子式:C22H18O10
分子量:442.37
纯度:98%
存储:Store at -20°C

Background:

(-)-epicatechin gallate is a major catechin component in green tea [1].


(-)-epicatechin gallate (ECG) plays an important role in cell growth inhibition, apoptosis and membrane transport system [1].


(-)-epicatechin gallate is a kind of catechin. In HCT-116 cells, ECG activated transcription factor 3 (ATF3), which played a critical role in pro-apoptosis. EGR-1 was involved in ECG-induced ATF3 expression. In HCT-116 cells, ECG (50 μM) increased NAG-1 and ATF3 expression in time- and dose-dependent way [1]. In carcinoma HSC-2 cells, ECG (50 μM) exhibited cytotoxicity with midpoint cytotoxicity (NR50) value of 67 μM. However, in normal HGF-2 fibroblasts, ECG exhibited cytotoxicity at concentrations up to 25 μM with NR50 value of 100 μM. In carcinoma HSC-2 cells, ECG (250 μM) induced nucleosomal DNA fragmentation and apoptosis. ECG (150 μM) significantly increased caspase-3 activity [2].


In rats, there were five metabolites of ECG: (-)-epicatechin gallate, 3’,4’’-di-O-methyl-(-)-epicatechin gallate, 4’’-O-methyl-(-)-epicatechin gallate, 4’-O-methyl-(-)-epicatechin gallate and 3’-O-methyl-(-)-epicatechin gallate, which were excreted in rat urine [3].


参考文献:
[1].  Cho KN, Sukhthankar M, Lee SH, et al. Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation. Eur J Cancer, 2007, 43(16): 2404-2412.
[2].  Babich H, Krupka ME, Nissim HA, et al. Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity. Toxicol In Vitro, 2005, 19(2): 231-242.
[3].  Kohri T, Suzuki M, Nanjo F. Identification of metabolites of (-)-epicatechin gallate and their metabolic fate in the rat. J Agric Food Chem, 2003, 51(18): 5561-5566.