20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils.
CAS：80434-82-8
分子式：C20H30O6
分子量：366.5
纯度：98%
存储：Store at -20°C

Background:

20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4. LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products. The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.