生物活性
PI-103是一种有效的，细胞可渗透的，ATP竞争性磷脂酰肌醇3激酶（PI3K）家族抑制剂，对DNA-PK，PI3K（p110α）和mTOR具有选择性。
Targets
| Target | Value |
| p110α | IC50: 2nM |
| p110β | IC50: 3nM |
| p110δ | IC50: 3nM |
| p110γ | IC50: 15nM |
| DNA-PK | IC50: 23nM |
| mTOR | IC50: 30nM |
化学数据
| 目录号 | A10726 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 348.4 |
| Formula | C19H16N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 371935-74-9 |
| Synonyms | PI103 |
| SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O |
溶解度
| In vitro (25°C) | DMSO | 22 mg/mL (63.15 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 1 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 28.7 mL | 143.51 mL | 287.03 mL |
| 0.5 mM | 5.74 mL | 28.7 mL | 57.41 mL |
| 1 mM | 2.87 mL | 14.35 mL | 28.7 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
*The above data is based on the productmolecular weight 348.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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