生物活性
Rapamycin (Sirolimus)是通过抑制T细胞和B细胞对白介素2(IL-2)的反应来防止其活化。
靶点信息
mTOR (HEK293 cells) | | | | |
~0.1 nM | | | | |
化学数据
目录号 | A10782 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 914.2 |
Formula | C51H79NO13 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 53123-88-9 |
Synonyms | Rapamune |
SMILES | C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC |
溶解度
In vitro (25°C) | DMSO | 18 mg/mL (19.68 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 10.94 mL | 54.69 mL | 109.39 mL |
0.5 mM | 2.19 mL | 10.94 mL | 21.88 mL |
1 mM | 1.09 mL | 5.47 mL | 10.94 mL |
5 mM | 0.22 mL | 1.09 mL | 2.19 mL |
*The above data is based on the productmolecular weight 914.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.