生物活性
Risperidone (Risperdal)是一种非典型的抗精神病药,用于治疗精神分裂症(包括青少年精神分裂症),精神分裂症,躁郁症的躁狂和躁狂状态,以及自闭症儿童的烦躁不安。
Targets
Target | Value |
5-HT2A | ki: 0.17nM |
α2c-adrenergicreceptor | ki: 1.3nM |
D2receptor | ki: 3.57nM |
D3receptor | ki: 3.6nM |
D2LReceptor | ki: 4.16nM |
D4receptor | ki: 4.66nM |
D2SReceptor | ki: 4.73nM |
α1A-adrenergicreceptor | ki: 5nM |
5-HT7 | ki: 6.6nM |
α1B-adrenergicreceptor | ki: 9nM |
5-HT2C | ki: 12nM |
5-HT1B | ki: 14.9nM |
α2a-adrenergicreceptor | ki: 16.5nM |
H1receptor | ki: 20.1nM |
5-HT2B | ki: 61.9nM |
5-HT1D | ki: 84.6nM |
α2b-adrenergicreceptor | ki: 108nM |
H2receptor | ki: 120nM |
5-HT5A | ki: 206nM |
5-HT5A | ki: 206nM |
D1receptor | ki: 244nM |
D5receptor | ki: 290nM |
5-HT1A | ki: 423nM |
5-HT6 | ki: 2060nM |
化学数据
目录号 | A10797 |
M. Wt | 410.5 |
Formula | C23H27FN4O2 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 106266-06-2 |
Synonyms | R 64 766, Risperdal |
SMILES | CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F |
溶解度
In vitro | DMSO | Warmed: 4 mg/mL (9.74 mM) |
Water | Insoluble |
Ethanol | 4 mg/mL (9.74 mM) |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 24.36 mL | 121.8 mL | 243.61 mL |
0.5 mM | 4.87 mL | 24.36 mL | 48.72 mL |
1 mM | 2.44 mL | 12.18 mL | 24.36 mL |
5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
*The above data is based on the productmolecular weight 410.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.