生物活性
Roflumilast可作为PDE-4酶的选择性长效抑制剂，无细胞试验中IC50为0.2-4.3 nM。
Targets
| Target | Value |
| PDE4B2 | IC50: 0.2nM |
| PDE4A1 | IC50: 0.7nM |
| PDE4B1 | IC50: 0.7nM |
| PDE4A4 | IC50: 0.9nM |
| PDE4C1 | IC50: 3nM |
| PDE4C2 | IC50: 4.3nM |
化学数据
| 目录号 | A10804 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 403.2 |
| Formula | C17H14Cl2F2N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 162401-32-3 |
| Synonyms | Daxas, Daliresp |
| SMILES | C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F |
溶解度
| In vitro (25°C) | DMSO | 70 mg/mL (173.6 mM) |
| Water | Insoluble |
| Ethanol | 13 mg/mL (32.24 mM) |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 24.8 mL | 124.01 mL | 248.02 mL |
| 0.5 mM | 4.96 mL | 24.8 mL | 49.6 mL |
| 1 mM | 2.48 mL | 12.4 mL | 24.8 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.96 mL |
*The above data is based on the productmolecular weight 403.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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