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S3I-201(NSC 74859)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S3I-201(NSC 74859)图片
CAS NO:501919-59-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
S3I201, NSC74859 , NSC-74859
产品介绍

生物活性

S3I-201(NSC 74859)是Stat3的新型抑制剂,可在体外抑制Stat3,Stat3复合物的形成以及Stat3-DNA结合活性(IC50 = 86±33 ?M)和Stat3依赖性转录活性。

靶点信息

STAT3 (Cell-free assay)
86 μM

化学数据

目录号A10817
作用机制Inhibitor (抑制剂)
M. Wt365.4
FormulaC16H15NO7S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.501919-59-1
SynonymsS3I201, NSC74859 , NSC-74859
SMILESCC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

溶解度

In vitro (25°C)DMSO66 mg/mL (180.64 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+corn oil2 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.37 mL136.84 mL273.67 mL
0.5 mM5.47 mL27.37 mL54.73 mL
1 mM2.74 mL13.68 mL27.37 mL
5 mM0.55 mL2.74 mL5.47 mL

*The above data is based on the productmolecular weight 365.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.