生物活性
S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。
靶点信息
| STAT3 (Cell-free assay) | | | | |
| 86 μM | | | | |
化学数据
| 目录号 | A10817 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 365.4 |
| Formula | C16H15NO7S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 501919-59-1 |
| Synonyms | S3I201, NSC74859 , NSC-74859 |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O |
溶解度
| In vitro (25°C) | DMSO | 66 mg/mL (180.64 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 5% DMSO+corn oil | 2 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 27.37 mL | 136.84 mL | 273.67 mL |
| 0.5 mM | 5.47 mL | 27.37 mL | 54.73 mL |
| 1 mM | 2.74 mL | 13.68 mL | 27.37 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.47 mL |
*The above data is based on the productmolecular weight 365.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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