您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > SB 203580
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SB 203580
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB 203580图片
CAS NO:152121-47-6
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
SB-203580, SB203580
产品介绍

生物活性

SB 203580是p38α和p38β的特异性抑制剂,可抑制MAPKAP激酶2和热激蛋白27的下游激活。

靶点信息

p38 MAPK (THP-1 cells)PKB (THP-1 cells)
0.3 μM-0.5 μM3 μM-5 μM

化学数据

目录号A10824
作用机制Inhibitor (抑制剂)
M. Wt377.4
FormulaC21H16FN3OS
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.152121-47-6
SynonymsSB-203580, SB203580
SMILESCS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

溶解度

In vitro (25°C)DMSO40 mg/mL (105.97 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+30% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM26.5 mL132.49 mL264.97 mL
0.5 mM5.3 mL26.5 mL52.99 mL
1 mM2.65 mL13.25 mL26.5 mL
5 mM0.53 mL2.65 mL5.3 mL

*The above data is based on the productmolecular weight 377.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.