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SB 525334
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB 525334图片
CAS NO:356559-20-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
SB-525334, SB525334
产品介绍

生物活性

SB525334是转化生长因子-β受体I(ALK5,TGF-βRI)的选择性抑制剂 (IC50 = 14.3 nM)。抑制TGF-β1诱导的smad2/3核定位和TGF-βRI诱导的肾细胞mRNA表达。

靶点信息

TGFβR1(ALK5) (Cell-free assay)
14.3 nM

化学数据

目录号A10827
作用机制Inhibitor (抑制剂)
M. Wt343.4
FormulaC21H21N5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.356559-20-1
SynonymsSB-525334, SB525334
SMILESCC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3

溶解度

In vitro (25°C)DMSO67 mg/mL (195.09 mM)
WaterInsoluble
Ethanol67 mg/mL (195.09 mM)
In vivo5% DMSO+corn oil19 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM29.12 mL145.6 mL291.21 mL
0.5 mM5.82 mL29.12 mL58.24 mL
1 mM2.91 mL14.56 mL29.12 mL
5 mM0.58 mL2.91 mL5.82 mL

*The above data is based on the productmolecular weight 343.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.