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SB 743921
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB 743921图片
CAS NO:940929-33-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
SB-743921, SB743921
产品介绍

生物活性

SB 743921是第二代KSP抑制剂,在癌症的临床前模型中是一种高效有效的治疗剂。

Targets

TargetValue
KSP(MX1cells)IC50: 0.06nM
KSP(Colo205cells)IC50: 0.07nM
KSPki: 0.1nM
KSP(SKOV3cells)IC50: 0.2nM
KSP(MV522cells)IC50: 1.7nM
KSP(P388cells)IC50: 14.4nM

化学数据

目录号A10828
作用机制Inhibitor (抑制剂)
M. Wt553.5
FormulaC31H33N2O3.HCl
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.940929-33-9
SynonymsSB-743921, SB743921
SMILESCC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl

溶解度

In vitro (25°C)DMSO103 mg/mL (186.08 mM)
Water20 mg/mL (36.13 mM)
Ethanol103 mg/mL (186.08 mM)
In vivoSaline pH5.028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.07 mL90.33 mL180.67 mL
0.5 mM3.61 mL18.07 mL36.13 mL
1 mM1.81 mL9.03 mL18.07 mL
5 mM0.36 mL1.81 mL3.61 mL

*The above data is based on the productmolecular weight 553.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.