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Semagacestat(LY450139)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Semagacestat(LY450139)图片
CAS NO:425386-60-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
LY-450139
产品介绍

生物活性

Semagacestat (LY450139)是一种针对Aβ42,Aβ40和Aβ38的γ-分泌酶阻滞剂,IC50分别为10.9 nM,12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导,IC50为14.1 nM。

靶点信息

γ secretase(Aβ42) (H4 human glioma cells)γ secretase(Aβ38) (H4 human glioma cells)γ secretase(Aβ40) (H4 human glioma cells)Notch (H4 human glioma cells)
10.9 nM12.0 nM12.1 nM14.1 nM

化学数据

目录号A10836
作用机制Inhibitor (抑制剂)
M. Wt361.4
FormulaC19H27N3O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.425386-60-3
SynonymsLY-450139
SMILESC[C@@H](C(=O)N[C@H]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O

溶解度

In vitro (25°C)DMSO66 mg/mL (182.6 mM)
WaterInsoluble
Ethanol38 mg/mL (105.13 mM)
In vivo0.5% methylcellulose28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.67 mL138.35 mL276.7 mL
0.5 mM5.53 mL27.67 mL55.34 mL
1 mM2.77 mL13.84 mL27.67 mL
5 mM0.55 mL2.77 mL5.53 mL

*The above data is based on the productmolecular weight 361.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.