生物活性
SRT1720 HCl是一种抑制剂,旨在作为瑟土因亚型SIRT1的小分子活化剂。
靶点信息
SIRT1 (Cell-free assay) | | | | |
0.16 μM(EC50) | | | | |
化学数据
目录号 | A10862 |
作用机制 | Activator (激活剂) |
M. Wt | 506.0 |
Formula | C25H23N7OS.HCl |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 1001645-58-4 |
Synonyms | SRT-1720 |
SMILES | C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl |
溶解度
In vitro | DMSO | 34 mg/mL (67.19 mM) |
Water | Insoluble |
Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 19.76 mL | 98.81 mL | 197.63 mL |
0.5 mM | 3.95 mL | 19.76 mL | 39.53 mL |
1 mM | 1.98 mL | 9.88 mL | 19.76 mL |
5 mM | 0.4 mL | 1.98 mL | 3.95 mL |
*The above data is based on the productmolecular weight 506.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.