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Staurosporine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Staurosporine图片
CAS NO:62996-74-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品名称
AM-2282, STS
产品介绍

生物活性

Staurosporine是一种天然产物,最初于1977年从Streptomyces staurosporeus细菌中分离出来。星形孢菌素的主要生物学活性是通过防止ATP与激酶的结合来抑制蛋白激酶。是一种有效的PKC抑制剂,在无细胞试验中作用于PKCα,PKCγ 和PKCη,IC50分别为2 nM,5 nM 和 4 nM,对PKCδ(20 nM)和PKCε(73 nM作用较弱,对PKCζ (1086 nM)的活性很低。同时 对其他的激酶PKA, PKG, S6K, CaMKII, 等也显示抑制活性。

Targets

TargetValue
PKCαIC50: 2nM
c-FgrIC50: 2nM
phosphorylasekinaseIC50: 3nM
PKCηIC50: 4nM
PKCγIC50: 5nM
S6kinaseIC50: 5nM
v-SrcIC50: 6nM
Cdc2IC50: 9nM
Cdc2IC50: 9nM
PKAIC50: 15nM
SykIC50: 16nM
PKGIC50: 18nM
PKCδIC50: 20nM
CaMKIIIC50: 20nM
LynIC50: 20nM
MLCKIC50: 21nM
PKCεIC50: 73nM
PKCζIC50: 1086nM

化学数据

目录号A10864
作用机制Inhibitor (抑制剂)
M. Wt466.5
FormulaC28H26N4O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.62996-74-1
SynonymsAM-2282, STS
SMILESC[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

溶解度

In vitroDMSO4 mg/mL (8.57 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.44 mL107.18 mL214.36 mL
0.5 mM4.29 mL21.44 mL42.87 mL
1 mM2.14 mL10.72 mL21.44 mL
5 mM0.43 mL2.14 mL4.29 mL

*The above data is based on the productmolecular weight 466.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.