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QS 11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
QS 11图片
CAS NO:944328-88-5
规格:98%
分子量:567.68
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
ARFGAP1 inhibitor,Wnt/beta-catenin pathway modulator
CAS:944328-88-5
分子式:C36H33N5O2
分子量:567.68
纯度:98%
存储:Store at -20°C

Background:

EC50: 1.5 μM for ARFGAP1 enzymatic assay [1] and 0.5 μM for Wnt synergist [2]


Purine derivative QS11 is a Wnt synergistic agonist by inhibiting the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1). ARFGAP1 promotes hydrolysis of ARF1-bound GTP and is required in membrane trafficking and /or vesicle transport.


In vitro: QS11 showed potent Wnt Synergist activity with little cytotoxicity in HEK293 cells (EC50 = 0.5 μM) and human primary fibroblast cells (EC50 ≥ 10 μM). QS11 at 2.5 μM activated the Super(8X)TOPFlash reporter