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Zaltoprofen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zaltoprofen图片
CAS NO:74711-43-6
规格:98%
分子量:298.36
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Cyclooxygenase (COX) inhibitor
CAS:74711-43-6
分子式:C17H14O3S
分子量:298.36
纯度:98%
存储:Store at -20°C

Background:

Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. Target: COXZaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen had a moderate inhibitory effect compared with those of the above-mentioned NSAIDs. the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses is not explainable by the inhibition of cyclooxygenase (COX). Zaltoprofen did not bind to B(1) and B(2) receptors in a radio-ligand binding assay. In the cultured dorsal root ganglion cells of mature mice, zaltoprofen completely inhibited the bradykinin-induced increase of [Ca(2+)](i), which was inhibited by B(2) antagonist D-Arg-[Hyp(3), Thi(5,8), D-Phe(7)]-bradykinin, but not by B(1) antagonist. [1].


参考文献:
[1]. Hirate, K., et al., Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res, 2006. 54(4): p. 288-94.