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Tandutinib(MLN518)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tandutinib(MLN518)图片
CAS NO:387867-13-2
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议

产品名称
MLN-518, CT53518
产品介绍

生物活性

Tandutinib (MLN518)是一种有效的FLT3抑制剂,c-KIT和PDGF受体酪氨酸激酶的自磷酸化,从而抑制细胞增殖并诱导细胞凋亡。

Targets

TargetValue
c-KitIC50: 0.17μM
PDGFRβIC50: 0.20μM
FLT3IC50: 0.22μM
CSF-1RIC50: 3.43μM
SrcIC50: 30μM
AblIC50: >30μM
PKCIC50: >30μM
PKAIC50: >30μM
MEK1IC50: >30μM
MKK4IC50: >30μM
MKK6IC50: >30μM
ERK2IC50: >30μM
p38IC50: >30μM
KDRIC50: >30μM
EGFRIC50: >30μM
FGFRIC50: >30μM
Insulin ReceptorIC50: >30μM

化学数据

目录号A10887
作用机制Inhibitor (抑制剂)
M. Wt562.7
FormulaC31H42N6O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.387867-13-2
SynonymsMLN-518, CT53518
SMILESCC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5

溶解度

In vitro (25°C)DMSO5 mg/mL (8.88 mM)
WaterInsoluble
Ethanol6 mg/mL (10.66 mM)
In vivo0.5% methylcellulose28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.77 mL88.86 mL177.71 mL
0.5 mM3.55 mL17.77 mL35.54 mL
1 mM1.78 mL8.89 mL17.77 mL
5 mM0.36 mL1.78 mL3.55 mL

*The above data is based on the productmolecular weight 562.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.