Ursocholicacid，一种存在于哺乳动物胆汁中的胆酸，是7α-羟化类固醇脱氢酶(7α-hydroxysteroiddehydrogenase)和肝细胞核因子1α(hepatocytenuclearfactor1α)的抑制剂。
CAS：2955-27-3
分子式：C24H40O5
分子量：408.57
纯度：98%
存储：Store at -20°C

Background:

Ursocholic acid, a bile acid found predominantly in bile of mammals, is an inhibitor of 7α-hydroxysteroid dehydrogenase and hepatocyte nuclear factor 1α.

[1]. MacDonald IA, et al. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms. Appl Environ Microbiol. 1982 Nov;44(5):1187-95. [2]. Lee HI, et al. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1α, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Nov;52(11):981-5.