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TSU-68(Orantinib,SU6668)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TSU-68(Orantinib,SU6668)图片
CAS NO:252916-29-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
TSU68
产品介绍

生物活性

TSU-68 (Orantinib,SU6668)在无细胞试验中具有8 nM的Ki对PDGFR自磷酸化的最大效力,但也强烈抑制Flk-1和FGFR1反磷酸化,对IGF-1R,Met,Src, Lck,Zap70,Abl和CDK2; 不抑制EGFR。

靶点信息

PDGFRβ (Cell-free assay)FGFR1 (Cell-free assay)Flk1 (Cell-free assay)
8 nM(Ki)1.2 μM(Ki)2.1 μM(Ki)

化学数据

目录号A10953
作用机制Inhibitor (抑制剂)
M. Wt310.4
FormulaC18H18N2O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.252916-29-3
SynonymsTSU68
SMILESCC1=C(NC(=C1CCC(=O)O)C)/C=C\2/C3=CC=CC=C3NC2=O

溶解度

In vitro (25°C)DMSO55 mg/mL (177.22 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% DMSO+30% polyethylene glycol+1% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM32.22 mL161.08 mL322.16 mL
0.5 mM6.44 mL32.22 mL64.43 mL
1 mM3.22 mL16.11 mL32.22 mL
5 mM0.64 mL3.22 mL6.44 mL

*The above data is based on the productmolecular weight 310.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.