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VX-680(MK-0457,Tozasertib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VX-680(MK-0457,Tozasertib)图片
CAS NO:639089-54-6
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

VX-680 (MK-0457,Tozasertib)是一种有效的选择性Aurora激酶小分子抑制剂。

靶点信息

Aurora A (Cell-free assay)Aurora C (Cell-free assay)Aurora B (Cell-free assay)FLT3 (Cell-free assay)Bcr-Abl (Cell-free assay)
0.6 nM(Ki app)4.6 nM(Ki app)18 nM(Ki app)30 nM(Ki)30 nM(Ki)

化学数据

目录号A10981
作用机制Inhibitor (抑制剂)
M. Wt464.6
FormulaC23H28N8OS
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.639089-54-6
SMILESCC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5

溶解度

In vitro (25°C)DMSO90 mg/mL (193.71 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+30% PEG 300+2% Tween 80+ddH2O14 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.52 mL107.62 mL215.24 mL
0.5 mM4.3 mL21.52 mL43.05 mL
1 mM2.15 mL10.76 mL21.52 mL
5 mM0.43 mL2.15 mL4.3 mL

*The above data is based on the productmolecular weight 464.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.