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VX-765(Belnacasan)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VX-765(Belnacasan)图片
CAS NO:273404-37-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
VX765
产品介绍

生物活性

VX-765 (Belnacasan)是一种新型的Caspase-1抑制剂,是一种控制两种细胞因子IL-1b和IL-18生成的酶。

靶点信息

Caspase-4 (Cell-free assay)Caspase-1 (Cell-free assay)
<0.6 nM(Ki)0.8 nM(Ki)

化学数据

目录号A10984
作用机制Inhibitor (抑制剂)
M. Wt509.0
FormulaC24H33ClN4O6
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.273404-37-8
SynonymsVX765
SMILESCCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl

溶解度

In vitro (25°C)DMSOWarmed: 87 mg/mL (170.92 mM)
WaterInsoluble
EthanolWarmed: 87 mg/mL (170.92 mM)
In vivo2% DMSO+30% PEG 300+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.65 mL98.23 mL196.46 mL
0.5 mM3.93 mL19.65 mL39.29 mL
1 mM1.96 mL9.82 mL19.65 mL
5 mM0.39 mL1.96 mL3.93 mL

*The above data is based on the productmolecular weight 509.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.