生物活性
VX-765 (Belnacasan)是一种新型的Caspase-1抑制剂,是一种控制两种细胞因子IL-1b和IL-18生成的酶。
靶点信息
Caspase-4 (Cell-free assay) | Caspase-1 (Cell-free assay) | | | |
<0.6 nM(Ki) | 0.8 nM(Ki) | | | |
化学数据
目录号 | A10984 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 509.0 |
Formula | C24H33ClN4O6 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 273404-37-8 |
Synonyms | VX765 |
SMILES | CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl |
溶解度
In vitro (25°C) | DMSO | Warmed: 87 mg/mL (170.92 mM) |
Water | Insoluble |
Ethanol | Warmed: 87 mg/mL (170.92 mM) |
In vivo | 2% DMSO+30% PEG 300+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 19.65 mL | 98.23 mL | 196.46 mL |
0.5 mM | 3.93 mL | 19.65 mL | 39.29 mL |
1 mM | 1.96 mL | 9.82 mL | 19.65 mL |
5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
*The above data is based on the productmolecular weight 509.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.