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VX-809(Lumacaftor)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VX-809(Lumacaftor)图片
CAS NO:936727-05-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
VX809
产品介绍

生物活性

VX-809 (Lumacaftor)是用于治疗囊性纤维化(CF)的第二种口服研究候选化合物,通过促进突变型CFTR(F508del-CFTR)的成熟,从而纠正囊性纤维症中常见的CFTR突变,在fisher大鼠甲状腺细胞中EC50为0.1 μM。

靶点信息

F508del-CFTR (Fisher rat thyroid cells)
0.1 μM(EC50)

化学数据

目录号A10986
作用机制Modulator (调节剂)
M. Wt452.4
FormulaC24H18F2N2O5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.936727-05-8
SynonymsVX809
SMILESCC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O

溶解度

In vitro (25°C)DMSO88 mg/mL (194.51 mM)
WaterInsoluble
Ethanol6 mg/mL (13.26 mM)
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.1 mL110.52 mL221.04 mL
0.5 mM4.42 mL22.1 mL44.21 mL
1 mM2.21 mL11.05 mL22.1 mL
5 mM0.44 mL2.21 mL4.42 mL

*The above data is based on the productmolecular weight 452.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.