生物活性
XL765是PI3K/mTOR双激酶抑制剂，与单独抑制PI3K激酶或mTOR激酶的药物相比，它的效力更高。
Targets
| Target | Value |
| PI3Kγ | IC50: 9nM |
| PI3Kα | IC50: 39nM |
| PI3Kδ | IC50: 43nM |
| PI3Kβ | IC50: 113nM |
| DNA-PK | IC50: 150nM |
| mTOR | IC50: 157nM |
化学数据
| 目录号 | A10997 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 599.7 |
| Formula | C31H29N5O6S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1349796-36-6 |
| Synonyms | XL-765 |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC |
溶解度
| In vitro (25°C) | DMSO | 10 mg/mL (16.68 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 16.68 mL | 83.38 mL | 166.75 mL |
| 0.5 mM | 3.34 mL | 16.68 mL | 33.35 mL |
| 1 mM | 1.67 mL | 8.34 mL | 16.68 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
*The above data is based on the productmolecular weight 599.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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