您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > XL765
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
XL765
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
XL765图片
CAS NO:1349796-36-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
XL-765
产品介绍

生物活性

XL765是PI3K/mTOR双激酶抑制剂,与单独抑制PI3K激酶或mTOR激酶的药物相比,它的效力更高。

Targets

TargetValue
PI3KγIC50: 9nM
PI3KαIC50: 39nM
PI3KδIC50: 43nM
PI3KβIC50: 113nM
DNA-PKIC50: 150nM
mTORIC50: 157nM

化学数据

目录号A10997
作用机制Inhibitor (抑制剂)
M. Wt599.7
FormulaC31H29N5O6S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1349796-36-6
SynonymsXL-765
SMILESCC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC

溶解度

In vitro (25°C)DMSO10 mg/mL (16.68 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM16.68 mL83.38 mL166.75 mL
0.5 mM3.34 mL16.68 mL33.35 mL
1 mM1.67 mL8.34 mL16.68 mL
5 mM0.33 mL1.67 mL3.34 mL

*The above data is based on the productmolecular weight 599.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.