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ZM-447439
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ZM-447439图片
CAS NO:331771-20-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
ZM447439
产品介绍

生物活性

ZM 447439是Aurora A和Aurora B的选择性和ATP竞争性抑制剂,IC50分别为110 nM和130 nM。它对Aurora A/B的选择性是MEK1,Src,Lck的8倍以上,对CDK1/2/4,Plk1,Chk1等的影响很小。

Targets

TargetValue
AuroraAIC50: 110nM
AuroraBIC50: 130nM
LCKIC50: 880nM
SrcIC50: 1.03μM
MEK1IC50: 1.79μM
CDK1IC50: >10μM
CDK2IC50: >10μM
CDK4IC50: >10μM
PLK1IC50: >10μM
Chk1IC50: >10μM
IKK1IC50: >10μM
IKK2IC50: >10μM
cFLT2IC50: >10μM
KDR2IC50: >10μM
ZAP70IC50: >10μM
FAKIC50: >10μM

化学数据

目录号A11009
作用机制Inhibitor (抑制剂)
M. Wt513.6
FormulaC29H31N5O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.331771-20-1
SynonymsZM447439
SMILESCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5

溶解度

In vitro (25°C)DMSO90 mg/mL (175.23 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.47 mL97.35 mL194.7 mL
0.5 mM3.89 mL19.47 mL38.94 mL
1 mM1.95 mL9.74 mL19.47 mL
5 mM0.39 mL1.95 mL3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.