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BKM120(NVP-BKM120,Buparlisib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BKM120(NVP-BKM120,Buparlisib)图片
CAS NO:944396-07-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

BKM120 (NVP-BKM120,Buparlisib)是生物可利用的口服泛I类磷脂酰肌醇3激酶(PI3K)激酶抑制剂,在无细胞试验中作用于p110α/β/δ/γ的。对VPS34,mTOR,DNAPK的作用效果下降,而对 PI4Kβ几乎没有活性。

Targets

TargetValue
p110αIC50: 52nM
p110δIC50: 116nM
p110βIC50: 166nM
p110γIC50: 262nM
Vps34IC50: 2.4μM
mTORIC50: 4.6μM
DNA-PKIC50: >5μM
PI4KβIC50: >25μM

化学数据

目录号A11016
作用机制Inhibitor (抑制剂)
M. Wt410.4
FormulaC18H21F3N6O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.944396-07-0
SMILESC1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4

溶解度

In vitro (25°C)DMSO76 mg/mL (185.18 mM)
WaterInsoluble
Ethanol2 mg/mL (4.87 mM)
In vivo5% DMSO+30% PEG 300+ddH2O14 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.37 mL121.83 mL243.66 mL
0.5 mM4.87 mL24.37 mL48.73 mL
1 mM2.44 mL12.18 mL24.37 mL
5 mM0.49 mL2.44 mL4.87 mL

*The above data is based on the productmolecular weight 410.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.