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PCI-32765(Ibrutinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PCI-32765(Ibrutinib)图片
CAS NO:936563-96-1
包装与价格:
包装价格(元)
10mg电议
25mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
Ibrutinib
产品介绍

生物活性

PCI-32765 (Ibrutinib)是Bruton酪氨酸激酶(BTK)的口服生物利用小分子抑制剂,具有潜在的抗肿瘤活性。对Bmx,CSK,FGR,BRK及HCK适度有效,对EGFR,Yes,ErbB2,JAK3等作用效果较弱。

Targets

TargetValue
BTKIC50: 0.5nM
BLKIC50: 0.5nM
BmxIC50: 0.8nM
CSKIC50: 2.3nM
FGRIC50: 2.3nM
BRKIC50: 3.3nM
HckIC50: 3.7nM
EGFRIC50: 5.6nM
YESIC50: 6.5nM
ErbB2IC50: 9.4nM
ITKIC50: 10.7nM
JAK3IC50: 16.1nM
FRKIC50: 29.2nM
LCKIC50: 33.2nM
RETIC50: 36.5nM
FLT3IC50: 73nM
TECIC50: 78nM
AblIC50: 86nM
FynIC50: 96nM
RIPK2IC50: 152nM
c-SrcIC50: 171nM
LynIC50: 200nM
PDGFRαIC50: 718nM
FmsIC50: 5.545μM
FERIC50: 8.07μM
JAK1IC50: >10μM
JAK2IC50: >10μM
NEK2IC50: >10μM
p38IC50: >10μM
PI3KIC50: >10μM
PLK1IC50: >10μM
RSK1IC50: >10μM
SykIC50: >10μM

化学数据

目录号A11020
作用机制Inhibitor (抑制剂)
M. Wt440.5
FormulaC25H24N6O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.936563-96-1
SynonymsIbrutinib
SMILESC=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N

溶解度

In vitro (25°C)DMSO81 mg/mL (183.88 mM)
WaterInsoluble
Ethanol41 mg/mL (93.07 mM)
In vivo5% DMSO+30% PEG 300+5% Tween 80+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.7 mL113.51 mL227.01 mL
0.5 mM4.54 mL22.7 mL45.4 mL
1 mM2.27 mL11.35 mL22.7 mL
5 mM0.45 mL2.27 mL4.54 mL

*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.