您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > NVP-AEW541
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
NVP-AEW541
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NVP-AEW541图片
CAS NO:475489-16-8
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
AEW541
产品介绍

生物活性

NVP-AEW541是一种选择性的IGF-1R激酶抑制剂,可抑制IGF-1R的自磷酸化活性(IC50 = 0.086 uM)并阻止IGF-1介导的MCF-7细胞存活和增殖(IC50分别为0.16和1.64 uM)。

化学数据

目录号A11021
作用机制Inhibitor (抑制剂)
M. Wt439.6
FormulaC27H29N5O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.475489-16-8
SynonymsAEW541
SMILESC1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6

溶解度

In vitro (25°C)DMSO77 mg/mL (175.18 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol19 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.75 mL113.74 mL227.48 mL
0.5 mM4.55 mL22.75 mL45.5 mL
1 mM2.27 mL11.37 mL22.75 mL
5 mM0.45 mL2.27 mL4.55 mL

*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.