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PF-04691502
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-04691502图片
CAS NO:1013101-36-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
PF04691502
产品介绍

生物活性

PF-04691502是PI3K/mTOR激酶抑制剂,也是在PI3K/mTOR信号传导途径中靶向磷脂酰肌醇3激酶(PI3K)和雷帕霉素(mTOR)哺乳动物靶标的药物。

Targets

TargetValue
PI3Kδki: 1.6nM
PI3Kαki: 1.8nM
PI3Kγki: 1.9nM
PI3Kβki: 2.1nM
P-Akt(S473)IC50: 3.8nM
P-Akt(T308)IC50: 7.5nM
mTORki: 16nM

化学数据

目录号A11024
作用机制Inhibitor (抑制剂)
M. Wt425.5
FormulaC22H27N5O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1013101-36-4
SynonymsPF04691502
SMILESCC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC

溶解度

In vitroDMSO13 mg/mL (30.55 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.5 mL117.51 mL235.02 mL
0.5 mM4.7 mL23.5 mL47 mL
1 mM2.35 mL11.75 mL23.5 mL
5 mM0.47 mL2.35 mL4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.