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Geldanamycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Geldanamycin图片
CAS NO:30562-34-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Geldanamycin与Hsp90的ATP位点(Kd = 1.2μM)结合并抑制其分子伴侣活性。

靶点信息

p185HSP90 (N-terminal domain)HSP90
70 nM0.78 μM(Kd)1.2 μM(Kd)

化学数据

目录号A11025
作用机制Inhibitor (抑制剂)
M. Wt560.6
FormulaC29H40N2O9
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.30562-34-6
SMILESC[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C/C=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)\C)OC)OC(=O)N)\C)C)O)OC

溶解度

In vitroDMSOWarmed: 32 mg/mL (57.08 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.84 mL89.19 mL178.38 mL
0.5 mM3.57 mL17.84 mL35.68 mL
1 mM1.78 mL8.92 mL17.84 mL
5 mM0.36 mL1.78 mL3.57 mL

*The above data is based on the productmolecular weight 560.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.