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GSK1120212(JTP-74057,Trametinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK1120212(JTP-74057,Trametinib)图片
CAS NO:871700-17-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
GSK-1120212, GSK212, Trametinib
产品介绍

生物活性

GSK1120212 (JTP-74057,Trametinib)强烈阻止了MEK1和MEK2激酶的活性,而不是其他98种激酶的活性。

靶点信息

MEK1 (Cell-free assay)MEK2 (Cell-free assay)
0.92 nM1.8 nM

化学数据

目录号A11029
作用机制Inhibitor (抑制剂)
M. Wt615.4
FormulaC26H23FIN5O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.871700-17-3
SynonymsGSK-1120212, GSK212, Trametinib
SMILESCC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

溶解度

In vitro (25°C)DMSOWarmed: 19 mg/mL (30.87 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+corn oil2 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM16.25 mL81.25 mL162.5 mL
0.5 mM3.25 mL16.25 mL32.5 mL
1 mM1.62 mL8.12 mL16.25 mL
5 mM0.32 mL1.62 mL3.25 mL

*The above data is based on the productmolecular weight 615.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.