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GSK690693
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK690693图片
CAS NO:937174-76-0
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
GSK-690693
产品介绍

生物活性

GSK690693是一种新型的ATP竞争性低纳摩尔泛Akt激酶抑制剂(IC50值分别为Akt1、2和3的2、13和9 nM)。

Targets

TargetValue
Akt1IC50: 2nM
PKCηIC50: 2nM
PKCθIC50: 2nM
PrkXIC50: 5nM
Akt3IC50: 9nM
Akt2IC50: 13nM
PKCδIC50: 14nM
PKCβIC50: 19nM
PKCεIC50: 21nM
PKAIC50: 24nM
PKG1βIC50: 33nM

化学数据

目录号A11030
作用机制Inhibitor (抑制剂)
M. Wt425.5
FormulaC21H27N7O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.937174-76-0
SynonymsGSK-690693
SMILESCCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N

溶解度

In vitro (25°C)DMSO36 mg/mL (84.61 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+40%PEG300+5% tween80+50% H2O2 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.5 mL117.51 mL235.02 mL
0.5 mM4.7 mL23.5 mL47 mL
1 mM2.35 mL11.75 mL23.5 mL
5 mM0.47 mL2.35 mL4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.