生物活性
Triciribine phosphate是一种DNA synthesis抑制剂,也抑制PC3细胞系中的Akt和CEM-SS,H9,H9IIIB,U1细胞中的HIV-1,IC50分别为130 nM和20 nM;对PI3K/PDK1没有抑制作用;作用于缺乏腺苷激酶的细胞,活性降低5000
化学数据
目录号 | A11033 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 400.3 |
Formula | C13H17N6O7P |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 61966-08-3 |
Synonyms | VQD-002,TCN-P |
SMILES | CN1C2=NC=NC3=C2C(=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(O)O)O)O)C(=N1)N |
溶解度
In vitro (25°C) | DMSO | 60 mg/mL (187.32 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 24.98 mL | 124.91 mL | 249.81 mL |
0.5 mM | 5 mL | 24.98 mL | 49.96 mL |
1 mM | 2.5 mL | 12.49 mL | 24.98 mL |
5 mM | 0.5 mL | 2.5 mL | 5 mL |
*The above data is based on the productmolecular weight 400.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.