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A-674563
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A-674563图片
CAS NO:552325-73-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
A674563
产品介绍

生物活性

A-674563是一种B/Akt抑制剂,IC50为14 nM,并且还显示出对PKA和CDK2的抑制活性,IC50分别为16和46 nM。

Targets

TargetValue
Akt1ki: 11nM
PKAki: 16nM
CDK2ki: 46nM
GSK-3βki: 110nM
ERK2ki: 260nM
PKCδki: 360nM
RSK2ki: 580nM
MAPK-AP2ki: 1.1μM
PKCγki: 1.2μM
FLT1ki: >2.2μM
Chk1ki: 2.6μM
KDRki: >3.7μM
CK2ki: 5.4μM
c-Kitki: >5.8μM
Srcki: 13μM
PDK-1ki: >20μM

化学数据

目录号A11034
作用机制Inhibitor (抑制剂)
M. Wt358.4
FormulaC22H22N4O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.552325-73-2
SynonymsA674563
SMILESCC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[C@H](CC4=CC=CC=C4)N

溶解度

In vitro (25°C)DMSO71 mg/mL (198.08 mM)
Water71 mg/mL (198.08 mM)
Ethanol18 mg/mL (50.21 mM)
In vivoSaline28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.9 mL139.51 mL279.02 mL
0.5 mM5.58 mL27.9 mL55.8 mL
1 mM2.79 mL13.95 mL27.9 mL
5 mM0.56 mL2.79 mL5.58 mL

*The above data is based on the productmolecular weight 358.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.