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GSK2126458(Omipalisib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK2126458(Omipalisib)图片
CAS NO:1086062-66-9
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
GSK-2126458
产品介绍

生物活性

GSK2126458 (Omipalisib)是一种高选择性的,有效的p110α/β/γ/δ和 mTORC1/2抑制剂,无细胞试验中Ki分别为0.019 nM/0.13 nM/0.024 nM/0.06 nM和0.18 nM/0.3 nM。

Targets

TargetValue
p110αki: 0.019nM
p110δki: 0.024nM
p110γki: 0.06nM
p110βki: 0.13nM
mTORC1ki: 0.18nM
mTORC2ki: 0.3nM

化学数据

目录号A11035
作用机制Inhibitor (抑制剂)
M. Wt505.5
FormulaC25H17F2N5O3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1086062-66-9
SynonymsGSK-2126458
SMILESCOC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F

溶解度

In vitro (25°C)DMSO96 mg/mL (189.91 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+40% PEG 300+2% Tween 80+ddH2O3 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.78 mL98.91 mL197.82 mL
0.5 mM3.96 mL19.78 mL39.56 mL
1 mM1.98 mL9.89 mL19.78 mL
5 mM0.4 mL1.98 mL3.96 mL

*The above data is based on the productmolecular weight 505.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.