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TAK-733
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAK-733图片
CAS NO:1035555-63-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
TAK733
产品介绍

生物活性

TAK-733是一种有效的,选择性的MEK变构抑制剂,作用于MEK1,IC50为3.2 nM,抑制Abl1,AKT3,c-RAF,CamK1,CDK2及c-Met等活性。

靶点信息

MEK1
3.2 nM

化学数据

目录号A11040
作用机制Inhibitor (抑制剂)
M. Wt504.2
FormulaC17H15F2IN4O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1035555-63-5
SynonymsTAK733
SMILESCN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)C[C@H](CO)O

溶解度

In vitroDMSO99 mg/mL (196.33 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.83 mL99.17 mL198.33 mL
0.5 mM3.97 mL19.83 mL39.67 mL
1 mM1.98 mL9.92 mL19.83 mL
5 mM0.4 mL1.98 mL3.97 mL

*The above data is based on the productmolecular weight 504.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.