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CHIR-124
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CHIR-124图片
CAS NO:405168-58-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议

产品名称
CHIR124
产品介绍

生物活性

CHIR-124是一种新型有效的Chk1抑制剂(Chk1和Chk2的IC50:分别为0.32 nM和697 nM)。

Targets

TargetValue
Chk1IC50: 0.3nM
FLT3IC50: 5.8nM
PDGFRIC50: 6.6nM
GSK-3IC50: 23.3nM
FynIC50: 98.8nM
PKAIC50: 103.1nM
PKCγIC50: 110nM
LCKIC50: 158.3nM
CDK2/CyclinAIC50: 191.1nM
VEGFR1/FLT1IC50: 463.6nM
Cdc2/CyclinBIC50: 505.7nM
VEGFR2/Flk1IC50: 577.9nM
PKCβ2IC50: 580nM
PKCαIC50: 580nM
Chk2IC50: 697.4nM
FGFR3IC50: 1.29μM
bFGFRIC50: 2.04μM
CDK4/CyclinDIC50: 2.05μM
PKAβ1IC50: 2.25μM
c-MetIC50: >3μM
ERK2IC50: 4.31μM
CABLIC50: 14.88μM

化学数据

目录号A11046
作用机制Inhibitor (抑制剂)
M. Wt419.9
FormulaC23H22ClN5O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.405168-58-3
SynonymsCHIR124
SMILESC1CN2CCC1[C@@H](C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl

溶解度

In vitro (25°C)DMSO6 mg/mL (14.29 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% DMSO+30% polyethylene glycol+1% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.82 mL119.08 mL238.15 mL
0.5 mM4.76 mL23.82 mL47.63 mL
1 mM2.38 mL11.91 mL23.82 mL
5 mM0.48 mL2.38 mL4.76 mL

*The above data is based on the productmolecular weight 419.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.