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OSI-906
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OSI-906图片
CAS NO:867160-71-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
OSI906, linsitinib
产品介绍

生物活性

OSI-906是一种选择性IGF-1R抑制剂,在无细胞试验中IC50为35 nM;对InsR抑制作用适中,IC50为75 nM,对Abl,ALK,BTK,EGFR, FGFR1/2,PKA等没有抑制活性。

Targets

TargetValue
IGF-1RIC50: 35nM
Insulin ReceptorIC50: 75nM
IRRIC50: 75nM
AblIC50: >10μM
ALKIC50: >10μM
BTKIC50: >10μM
EGFRIC50: >10μM
EphA1IC50: >10μM
EphB1IC50: >10μM
FESIC50: >10μM
FGFR1IC50: >10μM
FGFR2IC50: >10μM
FynIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
ROCK1IC50: >10μM
IRAK4IC50: >10μM
JAK2IC50: >10μM
KDRIC50: >10μM
LCKIC50: >10μM
LynAIC50: >10μM
LynBIC50: >10μM
MetIC50: >10μM
TrkAIC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
FAKIC50: >10μM
BRKIC50: >10μM
RETIC50: >10μM
Pim1IC50: >10μM
CDK1IC50: >10μM
DYRK2IC50: >10μM
SrcIC50: >10μM
TekIC50: >10μM
MEK1IC50: >10μM
Akt1IC50: >10μM
Akt2IC50: >10μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
PDK-1IC50: >10μM
PLK1IC50: >10μM
p38αIC50: >10μM
ERK1IC50: >10μM
GSK-3αIC50: >10μM
p70S6KIC50: >10μM

化学数据

目录号A11053
作用机制Inhibitor (抑制剂)
M. Wt421.5
FormulaC26H23N5O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.867160-71-2
SynonymsOSI906, linsitinib
SMILESCC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O

溶解度

In vitro (25°C)DMSO80 mg/mL (189.8 mM)
WaterInsoluble
EthanolInsoluble
In vivo5%DMSO+40%PEG300+5%Tween80+50%ddH2O5.93 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.72 mL118.62 mL237.25 mL
0.5 mM4.74 mL23.72 mL47.45 mL
1 mM2.37 mL11.86 mL23.72 mL
5 mM0.47 mL2.37 mL4.74 mL

*The above data is based on the productmolecular weight 421.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.