生物活性
Abiraterone Acetate是Abiraterone的醋酸盐形式,是一种甾体类细胞色素CYP17抑制剂。
靶点信息
CYP17 (Cell-free assay) | | | | |
72 nM | | | | |
化学数据
目录号 | A11058 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 391.3 |
Formula | C26H33NO2 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 154229-18-2 |
Synonyms | CB-7630 |
SMILES | CC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC=C4C5=CN=CC=C5)C)C |
溶解度
In vitro (25°C) | DMSO | Insoluble |
Water | Insoluble |
Ethanol | 27 mg/mL |
In vivo | 5% DMSO+95% Corn oil | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 25.56 mL | 127.78 mL | 255.56 mL |
0.5 mM | 5.11 mL | 25.56 mL | 51.11 mL |
1 mM | 2.56 mL | 12.78 mL | 25.56 mL |
5 mM | 0.51 mL | 2.56 mL | 5.11 mL |
*The above data is based on the productmolecular weight 391.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.