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BMS-754807
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS-754807图片
CAS NO:1001350-96-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
BMS754807, BMS 754807
产品介绍

生物活性

BMS-754807是一种有效的,口服活性生长因子1受体/胰岛素受体家族靶向的激酶抑制剂。

Targets

TargetValue
Insulin ReceptorIC50: 1.7nM
IGF-1RIC50: 1.8nM
TrkBIC50: 4.1nM
MetIC50: 5.6nM
TrkAIC50: 7.4nM
AuroraAIC50: 9nM
AuroraBIC50: 25nM
RONIC50: 44nM
FLT3IC50: 170nM
JAK2IC50: 347nM
GSK-3βIC50: 785nM
CDK2EIC50: 795nM
MK2IC50: 919nM
LCKIC50: 1.218μM
SrcIC50: 1.527μM
PKAIC50: 1.605μM
PKCαIC50: 2.53μM
BTKIC50: 3.797μM
CSKIC50: 5μM
PKCδIC50: 12μM
PKCζIC50: >50μM
PKCιIC50: >50μM
p38αIC50: >50μM
p38βIC50: >50μM
HER1IC50: >50μM
IKK1IC50: >50μM
IKK2IC50: >50μM

化学数据

目录号A11059
作用机制Inhibitor (抑制剂)
M. Wt461.5
FormulaC23H24FN9O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1001350-96-4
SynonymsBMS754807, BMS 754807
SMILESC[C@]1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F

溶解度

In vitro (25°C)DMSO86 mg/mL (186.35 mM)
WaterInsoluble
Ethanol86 mg/mL
In vivo2% DMSO+30% PEG 300+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.67 mL108.34 mL216.68 mL
0.5 mM4.33 mL21.67 mL43.34 mL
1 mM2.17 mL10.83 mL21.67 mL
5 mM0.43 mL2.17 mL4.33 mL

*The above data is based on the productmolecular weight 461.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.