生物活性
CX-4945 (Silmitasertib)是有效的，选择性CK2(casein kinase 2)抑制剂，可抑制人脐静脉内皮细胞迁移，管形成，并阻止癌细胞中CK2依赖性缺氧诱导的因子1α（HIF-1α）转录。
靶点信息
| CK2 (Cell-free assay) | | | | |
| 1 nM | | | | |
化学数据
| 目录号 | A11060 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 349.8 |
| Formula | C19H12ClN3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1009820-21-6 |
| Synonyms | Silmitasertib, CX 4945, CX4945 |
| SMILES | C1=CC(=CC(=C1)Cl)NC2=C3C=CN=CC3=C4C=CC(=CC4=N2)C(=O)O |
溶解度
| In vitro (25°C) | DMSO | 14 mg/mL (40.02 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 1% CMC Na | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 28.59 mL | 142.94 mL | 285.88 mL |
| 0.5 mM | 5.72 mL | 28.59 mL | 57.18 mL |
| 1 mM | 2.86 mL | 14.29 mL | 28.59 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.72 mL |
*The above data is based on the productmolecular weight 349.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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