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CX-4945(Silmitasertib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CX-4945(Silmitasertib)图片
CAS NO:1009820-21-6
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
Silmitasertib, CX 4945, CX4945
产品介绍

生物活性

CX-4945 (Silmitasertib)是有效的,选择性CK2(casein kinase 2)抑制剂,可抑制人脐静脉内皮细胞迁移,管形成,并阻止癌细胞中CK2依赖性缺氧诱导的因子1α(HIF-1α)转录。

靶点信息

CK2 (Cell-free assay)
1 nM

化学数据

目录号A11060
作用机制Inhibitor (抑制剂)
M. Wt349.8
FormulaC19H12ClN3O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1009820-21-6
SynonymsSilmitasertib, CX 4945, CX4945
SMILESC1=CC(=CC(=C1)Cl)NC2=C3C=CN=CC3=C4C=CC(=CC4=N2)C(=O)O

溶解度

In vitro (25°C)DMSO14 mg/mL (40.02 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% CMC Na28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM28.59 mL142.94 mL285.88 mL
0.5 mM5.72 mL28.59 mL57.18 mL
1 mM2.86 mL14.29 mL28.59 mL
5 mM0.57 mL2.86 mL5.72 mL

*The above data is based on the productmolecular weight 349.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.