生物活性
YM201636是PIKfyve的细胞渗透性和选择性抑制剂(IC50 = 33 nM)。
靶点信息
化学数据
目录号 | A11064 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 467.5 |
Formula | C25H21N7O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 371942-69-7 |
Synonyms | YM-201636 |
SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)NC(=O)C6=CN=C(C=C6)N |
溶解度
In vitro | DMSO | 31 mg/mL (66.3 mM) |
Water | Insoluble |
Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 21.39 mL | 106.95 mL | 213.9 mL |
0.5 mM | 4.28 mL | 21.39 mL | 42.78 mL |
1 mM | 2.14 mL | 10.7 mL | 21.39 mL |
5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
*The above data is based on the productmolecular weight 467.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.