您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CX-5461
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CX-5461
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CX-5461图片
CAS NO:1138549-36-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
CX5461
产品介绍

生物活性

CX-5461是RNA聚合酶I(Pol I)的一流的非遗传毒性小分子靶向抑制剂,可激活p53途径而不会引起DNA损伤。

靶点信息

A375MIA PaCa-2Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells)HCT-116
58 nM(ED50)74 nM(ED50)142 nM167 nM(ED50)

化学数据

目录号A11065
作用机制Inhibitor (抑制剂)
M. Wt513.6
FormulaC27H27N7O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1138549-36-6
SynonymsCX5461
SMILESCC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C

溶解度

In vitroDMSO<1 mg/mL
WaterInsoluble
EthanolDMF: Warmed: 3 mg/mL (5.84 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.47 mL97.35 mL194.7 mL
0.5 mM3.89 mL19.47 mL38.94 mL
1 mM1.95 mL9.74 mL19.47 mL
5 mM0.39 mL1.95 mL3.89 mL

*The above data is based on the productmolecular weight 513.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.