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Anacetrapib(MK-0859)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anacetrapib(MK-0859)图片
CAS NO:875446-37-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
MK0859
产品介绍

生物活性

Anacetrapib (MK-0859)是一种有效的,选择性,可逆的rhCETP和突变CETP(C13S)抑制剂,IC50分别为7.9 nM和11.8 nM,提高HDL-C,降低LDL-C,不提高醛固酮和血压。

化学数据

目录号A11084
作用机制Inhibitor (抑制剂)
M. Wt637.5
FormulaC30H25F10NO3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.875446-37-0
SynonymsMK0859
SMILESC[C@H]1[C@H](OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F

溶解度

In vitro (25°C)DMSO108 mg/mL (169.41 mM)
WaterInsoluble
Ethanol108 mg/mL (169.41 mM)
In vivo30% PEG400+0.5% Tween80+5% propylene glycol9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM15.69 mL78.43 mL156.86 mL
0.5 mM3.14 mL15.69 mL31.37 mL
1 mM1.57 mL7.84 mL15.69 mL
5 mM0.31 mL1.57 mL3.14 mL

*The above data is based on the productmolecular weight 637.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.