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AS-252424
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AS-252424图片
CAS NO:900515-16-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
AS252424
产品介绍

生物活性

AS-252424是有效的PI3K抑制剂,对γ亚型具有选择性。它抑制人重组PI3Kγ,α,β和δ,IC50值分别为30、940、20,000和20,000 nM。

靶点信息

Casein Kinase 2 (Cell-free assay)PI3Kγ (Cell-free assay)PI3Kα (Cell-free assay)
20 nM33 nM935 nM

化学数据

目录号A11099
作用机制Inhibitor (抑制剂)
M. Wt305.3
FormulaC14H8FNO4S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.900515-16-4
SynonymsAS252424
SMILESC1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3

溶解度

In vitro (25°C)DMSO57 mg/mL (186.71 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+50% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM32.75 mL163.77 mL327.55 mL
0.5 mM6.55 mL32.75 mL65.51 mL
1 mM3.28 mL16.38 mL32.75 mL
5 mM0.66 mL3.28 mL6.55 mL

*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.