生物活性
canagliflozin是2型亚钠葡萄糖转运蛋白(SGLT2)的抑制剂,作用于hSGLT2,无细胞试验中IC50为2.2 nM,比作用于hSGLT1选择性高413倍。
靶点信息
mSGLT2 (Cell-free assay) | rSGLT2 (Cell-free assay) | hSGLT2 (Cell-free assay) | | |
2 nM | 3.7 nM | 4.4 nM | | |
化学数据
目录号 | A11100 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 444.5 |
Formula | C24H25FO5S |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 842133-18-0 |
SMILES | CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F |
溶解度
In vitro (25°C) | DMSO | 79 mg/mL (177.71 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 0.5% CMC+0.25% Tween 80 | 17 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 22.5 mL | 112.49 mL | 224.97 mL |
0.5 mM | 4.5 mL | 22.5 mL | 44.99 mL |
1 mM | 2.25 mL | 11.25 mL | 22.5 mL |
5 mM | 0.45 mL | 2.25 mL | 4.5 mL |
*The above data is based on the productmolecular weight 444.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.