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Canagliflozin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Canagliflozin图片
CAS NO:842133-18-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

canagliflozin是2型亚钠葡萄糖转运蛋白(SGLT2)的抑制剂,作用于hSGLT2,无细胞试验中IC50为2.2 nM,比作用于hSGLT1选择性高413倍。

靶点信息

mSGLT2 (Cell-free assay)rSGLT2 (Cell-free assay)hSGLT2 (Cell-free assay)
2 nM3.7 nM4.4 nM

化学数据

目录号A11100
作用机制Inhibitor (抑制剂)
M. Wt444.5
FormulaC24H25FO5S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.842133-18-0
SMILESCC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F

溶解度

In vitro (25°C)DMSO79 mg/mL (177.71 mM)
WaterInsoluble
EthanolInsoluble
In vivo0.5% CMC+0.25% Tween 8017 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.5 mL112.49 mL224.97 mL
0.5 mM4.5 mL22.5 mL44.99 mL
1 mM2.25 mL11.25 mL22.5 mL
5 mM0.45 mL2.25 mL4.5 mL

*The above data is based on the productmolecular weight 444.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.