生物活性
Saxagliptin (BMS-477118)是一种新型二肽基肽酶4（DPP-4）抑制剂，IC50为50 nM。
靶点信息
化学数据
| 目录号 | A11109 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 315.4 |
| Formula | C18H25N3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 361442-04-8 |
| Synonyms | BMS-477118,Onglyza |
| SMILES | C1[C@@H]2C[C@@H]2N([C@@H]1C#N)C(=O)[C@H](C34CC5CC(C3)CC(C5)(C4)O)N |
溶解度
| In vitro (25°C) | DMSO | 62 mg/mL (196.57 mM) |
| Water | 62 mg/mL (196.57 mM) |
| Ethanol | 24 mg/mL (76.09 mM) |
| In vivo | Saline | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 31.71 mL | 158.53 mL | 317.06 mL |
| 0.5 mM | 6.34 mL | 31.71 mL | 63.41 mL |
| 1 mM | 3.17 mL | 15.85 mL | 31.71 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.34 mL |
*The above data is based on the productmolecular weight 315.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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