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TH-302(Evofosfamide)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TH-302(Evofosfamide)图片
CAS NO:918633-87-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
TH302
产品介绍

生物活性

TH-302 (Evofosfamide)是选择性靶向实体瘤缺氧激活的前体药物,靶向作用于实体瘤的hypoxic区域,IC50为19 nM,在缺氧条件下比在有氧条件下细胞毒性增强270倍,细胞色素P450代谢稳定。

靶点信息

化学数据

目录号A11144
M. Wt449.0
FormulaC9H16Br2N5O4P
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.918633-87-1
SynonymsTH302
SMILESCN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr

溶解度

In vitro (25°C)DMSO80 mg/mL (178.15 mM)
WaterWarmed: 9 mg/mL (20.03 mM)
Ethanol80 mg/mL (178.15 mM)
In vivo30% propylene glycol, 5% Tween 80, 65% D5W28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.27 mL111.36 mL222.72 mL
0.5 mM4.45 mL22.27 mL44.54 mL
1 mM2.23 mL11.14 mL22.27 mL
5 mM0.45 mL2.23 mL4.45 mL

*The above data is based on the productmolecular weight 449.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.