生物活性
TH-302 (Evofosfamide)是选择性靶向实体瘤缺氧激活的前体药物,靶向作用于实体瘤的hypoxic区域,IC50为19 nM,在缺氧条件下比在有氧条件下细胞毒性增强270倍,细胞色素P450代谢稳定。
靶点信息
化学数据
目录号 | A11144 |
M. Wt | 449.0 |
Formula | C9H16Br2N5O4P |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 918633-87-1 |
Synonyms | TH302 |
SMILES | CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr |
溶解度
In vitro (25°C) | DMSO | 80 mg/mL (178.15 mM) |
Water | Warmed: 9 mg/mL (20.03 mM) |
Ethanol | 80 mg/mL (178.15 mM) |
In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 22.27 mL | 111.36 mL | 222.72 mL |
0.5 mM | 4.45 mL | 22.27 mL | 44.54 mL |
1 mM | 2.23 mL | 11.14 mL | 22.27 mL |
5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
*The above data is based on the productmolecular weight 449.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.