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BX-795
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BX-795图片
CAS NO:702675-74-9
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
BX795
产品介绍

生物活性

BX-795是有效的PDK1抑制剂,可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。

Targets

TargetValue
TBK1/IKK?
PDK-1IC50: 6nM
c-KitIC50: 320nM
CDK2/CyclinEIC50: 430nM
Chk1IC50: 510nM
GSK-3βIC50: 620nM
PKAIC50: 840nM
KDRIC50: 1.1μM
T-FynIC50: 6.4μM
PKCIC50: 9.3μM
EGFRIC50: >10μM
Insulin ReceptorIC50: >10μM

化学数据

目录号A11148
作用机制Inhibitor (抑制剂)
M. Wt591.5
FormulaC23H26IN7O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.702675-74-9
SynonymsBX795
SMILESC1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

溶解度

In vitro (25°C)DMSO88 mg/mL (148.78 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+30% PEG +2% Tween 80+ddH2O3 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM16.91 mL84.53 mL169.06 mL
0.5 mM3.38 mL16.91 mL33.81 mL
1 mM1.69 mL8.45 mL16.91 mL
5 mM0.34 mL1.69 mL3.38 mL

*The above data is based on the productmolecular weight 591.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.