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BX-912
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BX-912图片
CAS NO:702674-56-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
BX912
产品介绍

生物活性

BX-912是3-磷酸肌醇依赖性激酶1(PDK1)的抑制剂。

Targets

TargetValue
PDK-1IC50: 12nM
PKAIC50: 110nM
KDRIC50: 410nM
CDK2/CyclinEIC50: 650nM
Chk1IC50: 830nM
c-KitIC50: 850nM
PKCIC50: 1.25μM
T-FynIC50: 2.1μM
Insulin ReceptorIC50: 6.1μM
GSK-3βIC50: 7.4μM
EGFRIC50: >10μM

化学数据

目录号A11149
作用机制Inhibitor (抑制剂)
M. Wt471.4
FormulaC20H23BrN8O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.702674-56-4
SynonymsBX912
SMILESC1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCC4=CN=CN4)Br

溶解度

In vitro (25°C)DMSO80 mg/mL (169.72 mM)
WaterInsoluble
Ethanol80 mg/mL (169.72 mM)
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.21 mL106.07 mL212.13 mL
0.5 mM4.24 mL21.21 mL42.43 mL
1 mM2.12 mL10.61 mL21.21 mL
5 mM0.42 mL2.12 mL4.24 mL

*The above data is based on the productmolecular weight 471.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.