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PCI-34051
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PCI-34051图片
CAS NO:950762-95-5
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
PCI34051
产品介绍

生物活性

PCI-34051是一种有效的特异性组蛋白脱乙酰基酶8(HDAC8)抑制剂,其选择性是其他HDAC亚型的200倍以上。

Targets

TargetValue
HDAC8IC50: 10nM
HDAC6IC50: 2.9μM
HDAC1IC50: 4μM
HDAC10IC50: 13μM
HDAC2IC50: >50μM
HDAC3IC50: >50μM

化学数据

目录号A11152
作用机制Inhibitor (抑制剂)
M. Wt296.3
FormulaC17H16N2O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.950762-95-5
SynonymsPCI34051
SMILESCOC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO

溶解度

In vitro (25°C)DMSO58 mg/mL (195.73 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+40%PEG300+5% tween80+50% H2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM33.75 mL168.75 mL337.5 mL
0.5 mM6.75 mL33.75 mL67.5 mL
1 mM3.37 mL16.87 mL33.75 mL
5 mM0.67 mL3.37 mL6.75 mL

*The above data is based on the productmolecular weight 296.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.