生物活性
PCI-34051是一种有效的特异性组蛋白脱乙酰基酶8(HDAC8)抑制剂,其选择性是其他HDAC亚型的200倍以上。
Targets
Target | Value |
HDAC8 | IC50: 10nM |
HDAC6 | IC50: 2.9μM |
HDAC1 | IC50: 4μM |
HDAC10 | IC50: 13μM |
HDAC2 | IC50: >50μM |
HDAC3 | IC50: >50μM |
化学数据
目录号 | A11152 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 296.3 |
Formula | C17H16N2O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 950762-95-5 |
Synonyms | PCI34051 |
SMILES | COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO |
溶解度
In vitro (25°C) | DMSO | 58 mg/mL (195.73 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 5% DMSO+40%PEG300+5% tween80+50% H2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 33.75 mL | 168.75 mL | 337.5 mL |
0.5 mM | 6.75 mL | 33.75 mL | 67.5 mL |
1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
*The above data is based on the productmolecular weight 296.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.